Rabbit Models for Alzheimer's Disease
- Submitted by:
- alex01
- DOI:
- 10.4016/9811.01
- Description:
-
Diana Woodruff-Pak (Temple University, Philadelphia, PA) used cholesterol-fed rabbits as a model of AD for evaluation of currently available and potential anti-Alzheimer drugs. These animals developed typical Alzheimer pathology, including behavioral changes and deposition of ß-amyloid and even tau. Galantamine and donepezil partially protected animals from Alzheimer symptomatology.
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- Thursday, February 5, 2009
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Tags
- abeta
- AD
- AD model
- Amyloid Prosecutor Protein
- anatomical
- APP
- arteries
- behavior level
- beta-amyloid
- biogenetic advantages
- brain aging
- brain circuitry
- cats
- cholesterol
- cholinergic system
- cholinesterase inhibitor
- CIR-CNS
- classical conditioning
- compounds
- Diana Woodruff-Pak
- disease prevention
- donepezil
- dose
- drinking water
- drug applicability
- drugs
- estrogen
- eye-blink conditioning
- frontal cortex
- galantamine
- Gregory M. Rose
- humans
- immunization
- immunization effect
- Journal of Alzheimer's Disease
- Larry Sparks
- mammals
- mechanism of action
- memantine
- mice
- molecular
- Neurology
- neurons
- neuropathology
- neuroscience meeting
- neuroscience Program Temple University
- NMDA antagonist
- numerical behavioral effect
- PA
- paradimes
- parallels
- Pennsylvannia
- PharmExperts.com
- philadelphia
- pre-clinical animal models
- psychology
- rabbit model
- Rabbit Models for Alzheimer's Disease
- rats
- results
- serum
- Southern Illinois University
- statistical significance
- synergistic effect
- therapies
- trace-cupper
- vaccinne
- young males
Subject areas
