Drug Discovery for Alzheimer's Disease
- Submitted by:
- alex01
- DOI:
- 10.4016/9788.01
- Description:
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Gregory Rose from PharmExperts.com interviews J. Buccafusco (Medical College of Georgia, Augusta, GA) about his development of new anti-Altzheimer drugs, designed to act by multiple mechanisms to improve congnition. Desensitization of nicotinic receptors is one of the novel approaches proposed by Buccafusco. Three of his compounds are currently in advanced preclinical evaluation.
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Tags
- a-beta
- activity
- activity h3 receptors
- AD
- Alzheimer's disease
- analgesic
- analogs of choline
- Anti-Alzheimer drugs
- antibodies
- Atlanta
- beta amyloid
- Binding Sites
- brain
- campus
- choline analogs
- cholinergic properties
- clinical development
- clinical IND
- CNS
- cognition
- cognition enhancement
- compounds
- Damage
- desensitizers
- disinhibition
- doses
- Drug Discovery
- feedback inhibition
- Georgia Institute of Technology
- Georgia Tech
- glutamate system
- Gregory M. Rose
- human behavior
- inflammation
- inhibitor
- Jerry J. Buccafusco
- JWB1-84-1
- JWS-USC-75-1X
- kinetic state
- m2 receptor
- Medical College of Georgia
- MHP133
- mixed muscarinic
- molecule
- monkeys
- mouse model
- nerve agent poisoning
- neuroprotection
- nicotine-like affects
- nicotinic
- nicotinic receptors
- non-human
- oral vaccine
- oxidative
- periphery
- pharmacological properties
- pharmacology
- PharmExperts
- PharmExperts.com
- plasma
- plasmin brain amyloid
- platform
- potency
- preliminary patent
- pro-convulsant
- proteins
- pseudo-protective effects
- psychiatry
- rage
- rats
- reaction time
- receptor desensitization
- rodents
- samples
- Schizophrenia
- side effects
- silent desensitizers
- Society for Neuroscience
- strategy
- targeting multiple drug targets
- tension enhancement
- therapeutics
- toxic effects
- Toxicology
- U.S. patents
- University of South Carolina
- vaccine
Subject areas
