surgery

Dr. Joseph Dearani, Consultant in Cardiovascular Surgery at Mayo Clinic, Rochester, MN, discusses his article (available at: http://tinyurl.com/25kt7m6 ) appearing in the December 2010 issue of Mayo Clinic Proceedings, describing surgical repair of tetralogy of fallot in adults.

Dr. Neal S. Leleiko discusses his manuscript "Factors That Determine Risk for Surgery in Pediatric Patients With Crohn's Disease". To view the print version of this abstract go to http://tiny.cc/6vrql

In this video, Daniel Berry, MD, Professor and Chairman of the Mayo Clinic Department of Orthopedic Surgery discusses the findings of a paper in which he and his coauthors evaluated the utilization rates of total hip and total knee arthroplasty from 1969-2008 in one county in MN.

Dr. Christine Heisler, female pelvic medicine and reconstructive surgeon at Spectrum Health, Grand Rapids, MI, discusses complication rates between local and referral patients undergoing vaginal hysterectomy at Mayo Clinic; this study was published in the February 2010 issue of Mayo Clinic Proceedings.

Michael Rogawski (University of California, Davis) summarizes his research on the antiepileptic activity of neurosteroids (e.g. ganaxolone, allopregnanolone). They are allosteric modulators of GABAA receptors and are active in many models of epilepsy. They are expected, however, to be most effective in catamenial epilepsy, infantile spasms or adult partial seizures. National Institutes of Health (NIH) is currently sponsoring a clinical trial of progesterone (precursor of allopregnanolone)...

R.A. Flavell (Yale University, New Haven, CT) discusses the role of Transforming Growth Factor ß (TGFß) in disease. In the central nervous system of a murine model of AD this cytokine appears to prevent macrophages from attacking ß-amyloid. Flavell visualizes that selective blockade of this TGFß activity could lead to the destruction of plaques in patients with AD.